I know hitman isn't a fighting game but in the case of not having any weapons and your in danger I think the melee system should be something under heavy consideration.
I liked how blood money introduced somewhat of a way to knock enemies out but it was too simple..either disarm or headbutt and a quick one-two punch.
Absolutions fighting was kind of tedious in a way. I also don't like pressing a sequence of buttons just to knock someone out.
In my opinion ( just an opinion so open for critisim but pls no arguments ) if anyone has played any of the batman games I think the fighting is fluent and amazing. Its sort of simple but fun. You have attack, (preferbly punch) takedowns, gadgets, ( not to necessary for a hitman in a fight) and last but not least the counter system( a little icon appears to press the counter button and leaves you open for attack or takedown). I'm not saying put emphasis on physical combat but if its needed I think they should have a free flow fighting system similar to this.
If anyone has any cool or interesting ideas I'd like to hear