You need to develop your protagonist if you want a good story. I don't like the idea of a story where the protagonist begins and ends as a paid tool. If the point of 47 continuing is that he enjoys his work, then maybe we can see a little more of where he is going with this side of his character.
Even better, if you want to erase the plot of Hitman: Absolution, then we can have another story where 47 gains independence from the ICA, maybe building up to it this time, instead of just having him fly off on a whim. This could make for some cool ideas for enemies and levels, maybe even some twists on equipment and planning phases. I hope I/O has some good writers for this one.